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當前位置：首頁產品中心重組蛋白Z03430TGF-β 3, Human

TGF-β 3, Human
產品簡介：

TGF-β 3, Human： a member of a TGF -β superfamily which is defined by their structural and functional similarities.

產品型號：Z03430

更新時間：2025-11-05

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產品介紹

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by their structural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset of integrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved in cell differentiation, embryogenesis and development. It is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.


產品簡介
SpeciesHuman
Protein Construction
TGF-β3 (Ala301-Ser412)
Accession # P10600
Purity> 95% as analyzed by SDS-PAGE
Endotoxin Level< 1 EU/μg of protein by LAL method
Biological ActivityMeasured by its ability to inhibit the IL-4-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 10-80pg/ml.
Expression SystemHuman Cells
Apparent Molecular Weight~12.7 kDa, on SDS-PAGE under reducing conditions.
FormulationLyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH 2.5.
ReconstitutionIt is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O up to 100 μg/ml.
Storage & StabilityUpon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. Avoid repeated freeze-thaw cycles.
技術背景
Target BackgroundTransforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by their structural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset of integrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved in cell differentiation, embryogenesis and development. It is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.
SynonymsTransforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP


For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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